Projects

  • Near-Causal Inference in Multi-omic Data

    Many diseases are associated with changes of the microbial composition in our gut. However, we are just beginning to understand the relationships between the bacteria living in our intestinal system and the physiology and health of our bodies. One of the particular challenges we face is determining the causal direction for host-microbial associations. For instance, we may observe that individuals with diabetes have a greater abundance of a particular bacterium…

  • Microbiome Stress Project

    We have joined researchers at Duke University, the University of New Hampshire, and Montana State University to conduct a large-scale meta-analysis of how environmental stressors impact microbial communities. Prior surveys, like the Earth and Human Microbiome Projects, have established a baseline for healthy ecosystems across the planet. The Microbiome Stress Project will focus on ecological resistance and resilience of natural microbial communities to disturbances. The meta-analysis encompasses hundreds of studies…

  • 100K Wellness Project

    We are collecting dense, dynamic molecular phenotypes from 100,000 people over the next several years. This large cross-disciplinary endeavor, called the 100K Wellness Project, spans multiple labs at ISB. We will integrate measurements of human physiology, immune function, and diet with measurements of the composition and functional potential of the gut microbiome. By tracking people undergoing disease transitions, we will build a set of hypotheses for how shifts in diet…