News

Timing is Everything: ISB Study Finds Link Between Bowel Movement Frequency and Overall Health

Everybody poops, but not every day. An ISB-led research team examined the clinical, lifestyle, and multi-omic data of more than 1,400 healthy adults. How often people poop, they found, can have a large influence on one’s physiology and health.

Hack Your Health: An Evening with Anjali Nayar and Dr. Sean Gibbons

Netflix’s “Hack Your Health: The Secrets of Your Gut” is a documentary that merged gut microbiome experts, four individuals – including a well-known hot dog eating champion – facing personal battles with gastrointestinal health, and a unique, effective visual method of “showing” the gut microbiome in action. 

A New Path Toward Microbiome-Informed Precision Nutrition

ISB researchers have developed a novel way to simulate personalized, microbiome-mediated responses to diet. They use a microbial community-scale metabolic modeling (MCMM) approach to predict individual-specific short-chain fatty acid production rates in response to different dietary, prebiotic, and probiotic inputs.

Making Nutrition and Healthcare Personalized, Predictive, and Preventive

Dr. Sean Gibbons is creating a new precision nutrition platform called My Digital Gut that leverages the gut microbiome to make nutrition and healthcare personalized, predictive, and preventive. In an ISB Research Roundtable presentation, Gibbons spoke about My Digital Gut and other microbiome-related projects studied in his lab.   

Dr. Sean Gibbons Promoted to Associate Professor

Dr. Sean Gibbons – an expert in microbial ecology and evolution, computational systems biology, the human gut microbiome and its impacts on health, and head of ISB’s Gibbons Lab – has been promoted to Associate Professor. “Sean’s achievements since joining ISB in 2018 as a Washington Research Foundation Distinguished Investigator have been spectacular,” ISB President Dr. Jim Heath said. “With his focus on the microbiome, he brought a whole new…

Bugs vs. Drugs: How Our Microbiomes Can Explain Our Response to Statins

ISB Assistant Professor Dr. Sean Gibbons talked about the science behind statins in our most recent Research Roundtable virtual presentation. His talk was titled “Bugs vs. Drugs: How Our Unique Gut Microbiomes Shape Our Personalized Responses to Statins.”

Microbiome and weight loss

Can You Lose Weight? Ask Your Microbiome

The strongest associations with weight loss success or failure – independent of BMI – are found in the genetic capacity of the gut microbiome. These new findings open the door to diagnostic tests that can identify people likely to lose weight with healthy lifestyle changes and those who might need more drastic interventions.

Overall composition of gut microbiome in participants

Variations in the Microbiome Associated with Health, Disease

ISB researchers examined the associations between the gut microbiomes of about 3,400 people and roughly 150 host characteristics. The team looked at diet, medication use, clinical blood markers, and other lifestyle and clinical factors, and found evidence that variations of the gut microbiome are associated with health and disease.

Bacterial tug of war between prevotella and bacteroides -- gut microbiome

It’s ‘Either/Or’ for Two Common Gut Microbiome Genera, and Switching Teams Is Tougher Than Expected

There is a dichotomy between Bacteroides- and Prevotella-dominated guts — two common gut bacterial genera — and there is a significant barrier when it comes to transitioning from one to the other.